Having originally been considered to be the lead-off single when Simon & Garfunkel’s Bridge Over Troubled Water album was released in 1970 (eventually losing out to the title track), the catchy and upbeat “Cecilia” eventually peaked at number 4 on the U.S. charts. Interestingly enough, the song also resonated quite well across the pond as it peaked at number 5 on the U.K. charts whereas the title track “Bridge Over Troubled Water” never cracked the top 75 there.
Over the years, it has been pretty firmly established that the song is not paying tribute to a specific musical muse named Cecilia. It is more likely that the reference is to Saint Cecilia the patron saint of musicians in the Catholic church. At the time “Cecilia” was released, it was fairly well established that the personal relationship between Paul Simon and Art Garfunkel was in serious turmoil and this was the last S&G before the initial breakup.